Eye complaints, Graves Disease Indicators

Graves' disease (Photo: Getty Images)

DISEASE Graves ( goiter difusa toksika ) is a form tiroktoksikosis (hyperthyroidism) are most often encountered in everyday life. This disease can happen to all ages, and often affects women than men.

Signs and symptoms of Graves' disease is the presence of goitre (diffuse hypertrophy and hyperplasia), thyrotoxicosis (hypersecretion of thyroid gland or hyperthyroidism) and is often accompanied oftalmopati, and accompanied dermopati, though rarely. Abnormalities of the eye that widened into the most important indicators of the disease.

"Abnormalities of the eye in Graves' disease is a thyroid manivestasi outside that often.'s Thyroid disease thyroid disease, thyroid disease outside of the most common is to the eye . Often the management of eye disorders a problem because it is often too late is known. Not paying attention to what often happens in the eye, so it eventually becomes difficult to treat, "said Dr. Dr. Imam Subekti, SpPD-KEMD when talking with Legal after hearing his PhD dissertation at the UI, Salemba , Jakarta, Tuesday (23/08/2011).

Telatnya overcome eye problems caused by the active thyroid gland to make the 53-year-examine the predictors of the disease.

"Generally the occurs thyroid gland or thyroid disease improved, but his eyes still did not improve. It being late when to start intensive treatment. Therefore, I try to look for predictors at what level predictors so that later it can be determined when to begin treatment. Because of concerns trouble managing thyroid disease , "said the father of three children.

This disease has a strong genetic predisposition, in which 15 percent of sufferers have a close family relationship with the same disease. About 50 percent of families with Graves' disease, thyroid autoantibodies are found in the blood.

"The problem is talent or genetic, so no one can predict that someone will be able to or not, so the most important thing is when subjected to the complaints of thyroid medication right away," he added.

In Graves' disease, T lymphocytes have antigen stimulation in the thyroid gland which in turn will stimulate B lymphocytes to synthesize antibodies to these antigens. Synthesized antibodies that will react with the TSH receptor in thyroid cell membranes so that it will stimulate the growth and function of thyroid cells, known as the TSH-R antibody.

The presence of antibodies in the blood circulation has a close correlation with disease activity and relapse. Otoimunitas mechanism is an important factor in the pathogenesis of hyperthyroidism, oftalmopati, and dermopati in Graves' disease. Until now there are three known major otoantigen of the thyroid gland thyroglobulin (Tg), thyroidal peroxidase (TPO) and TSH receptor (TSH-R).

(NSA)